Article

INPP5E controls ciliary localization of phospholipids and odor response kinetics in a mouse model of Joubert syndrome

2018-10-23

Abstract excerpt

Ciliopathies manifested in part by a dysfunction of several phosphoinositide 5’phosphatases constitute Lowes, Dent disease 2 and Joubert syndromes through critical involvement of properly functioning primary cilia (PC). We showed that deletion of INPP5E under the control of OMP-Cre in mature mouse olfactory sensory neurons (OSNs) led to a dramatic redistribution of PI(4,5)P2 (PIP2) in cilia, significant reduction...

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Identifiers and source

Literature Corpus work: 1256ae8c-38ed-50af-a30c-86c306072b97
DOI: 10.1101/451344

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