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Article

Inhibition of Soluble Epoxide Hydrolase Ameliorates Phenotype and Cognitive Abilities in a Murine Model of Niemann Pick Type C Disease.

International journal of molecular sciences - 26 Mar 2021

Griñán-Ferré Christian, Companys-Alemany Júlia, Jarné-Ferrer Júlia, Codony Sandra, González-Castillo Celia, Ortuño-Sahagún Daniel, Vilageliu Lluïsa, Grinberg Daniel, Vázquez Santiago, Pallàs Mercè

Abstract excerpt

Niemann-Pick type C (NPC) disease is a rare autosomal recessive inherited childhood neurodegenerative disease characterized by the accumulation of cholesterol and glycosphingolipids, involving the autophagy-lysosome system. Inhibition of soluble epoxide hydrolase (sEH), an enzyme that metabolizes epoxy fatty acids (EpFAs) to 12-diols, exerts beneficial effects in modulating inflammation and autophagy, critical...

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PMID: 33810307
DOI: 10.3390/ijms22073409
PMCID: PMC8036710

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