Article

TFF3 is a ligand for LINGO2 that de-represses EGFR to control disease outcome during colitis and gastrointestinal nematode infection

2018-11-13

Abstract excerpt

<h4>Summary</h4> Intestinal epithelial cells (IEC) comprise diverse lineages that serve distinct roles necessary for regulation of nutrient absorption, regeneration, immunity, and homeostasis 1,2 . Goblet cells secrete Trefoil factor 3 (TFF3) to maintain mucus viscosity and drive mucosal healing by inhibiting cell death and influencing tight junction protein expression 3 . However, whether TFF3 signaling relies...

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Literature Corpus work: 47b7f7cb-2b21-5feb-a659-9ab4d6eaa154
DOI: 10.1101/469700

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