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Article

Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency.

Gastroenterology - 1 Jul 2009

Podolsky Daniel K, Gerken Guido, Eyking Annette, Cario Elke

Abstract excerpt

BACKGROUND & AIMS: Goblet cells (GC) facilitate mucosal protection and epithelial barrier repair, yet the innate immune mechanisms that selectively drive GC functions have not been defined. The aim of this study was to determine whether Toll-like receptor (TLR) 2 and modulation of GC-derived trefoil factor (TFF) 3 are functionally linked in the intestine. METHODS: GC modulation was assessed using quantitative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19303021
DOI: 10.1053/j.gastro.2009.03.007
PMCID: PMC2812790

Genes

TLR2
TFF3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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