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Article

Mutational landscape of chronic myeloid leukemia: more than a single oncogene leukemia.

Leukemia & lymphoma - 1 Sept 2021

Adnan-Awad Shady, Kankainen Matti, Mustjoki Satu

Abstract excerpt

The BCR-ABL1 fusion gene, which causes aberrant kinase activity and uncontrolled cell proliferation, is the hallmark of chronic myeloid leukemia (CML). The development of tyrosine kinase inhibitors (TKI) that target the BCR-ABL oncoprotein has led to dramatic improvement in CML management. However, some challenges remain to be addressed in the TKI era, including patient stratification and the selection of...

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Share to Acute Myeloid Leukemia Research
Share to Chronic Myeloid Leukemia Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Fusion Proteins, bcr-abl

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Identifiers

PMID: 33944660
DOI: 10.1080/10428194.2021.1894652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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