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Article

Mutations in myeloid transcription factors and activated signaling genes predict chronic myeloid leukemia outcomes.

Blood advances - 28 May 2024

Perusini Maria Agustina, Žáčková Daniela, Kim Taehyung, Pagnano Katia, Pavlovsky Carolina, Ježíšková Ivana, Kvetková Anežka, Jurček Tomáš, Kim Jaeyoon, Yoo Youngseok, Yi Seongyoon, Lee Hyewon, Kim Kyoung Ha, Chang Myunghee, Capo-Chichi Jose-Mario, Medeiros Jessie J F, Arruda Andrea, Minden Mark, Zhang Zhaolei, Abelson Sagi, Mayer Jiri, Hwan Kim Dennis Dong

Abstract excerpt

ABSTRACT: Advancements in genomics are transforming the clinical management of chronic myeloid leukemia (CML) toward precision medicine. The impact of somatic mutations on treatment outcomes is still under debate. We studied the association of somatic mutations in epigenetic modifier genes and activated signaling/myeloid transcription factors (AS/MTFs) with disease progression and treatment failure in patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Identifiers

PMID: 38447114
DOI: 10.1182/bloodadvances.2023012127
PMCID: PMC11127220

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