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Article

Unexpected Heterodivalent Recruitment of NOS1AP to nNOS Reveals Multiple Sites for Pharmacological Intervention in Neuronal Disease Models.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 May 2015

Li Li-Li, Melero-Fernandez de Mera Raquel M, Chen Jia, Ba Wei, Kasri Nael Nadif, Zhang Mingjie, Courtney Michael J

Abstract excerpt

The protein NOS1AP/CAPON mediates signaling from a protein complex of NMDA receptor, PSD95 and nNOS. The only stroke trial for neuroprotectants that showed benefit to patients targeted this ternary complex. NOS1AP/nNOS interaction regulates small GTPases, iron transport, p38MAPK-linked excitotoxicity, and anxiety. Moreover, the nos1ap gene is linked to disorders from schizophrenia, post-traumatic stress disorder,...

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PMID: 25972165
DOI: 10.1523/JNEUROSCI.0037-15.2015
PMCID: PMC6705433

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