Article

S-Nitrosylation of CRTC1 in Alzheimer’s disease impairs CREB-dependent gene expression induced by neuronal activity

2023-08-27

Abstract excerpt

<h4>SUMMARY</h4> CREB-regulated transcription coactivator 1 (CRTC1) plays an important role in synaptic plasticity, learning and long-term memory formation through regulation of neuronal activity-dependent gene expression, and CRTC1 dysregulation is implicated in Alzheimer’s disease (AD). Here, we show that increased S-nitrosylation of CRTC1 (forming SNO-CRTC1), as seen in cell-based, animal-based, and human indu...

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Literature Corpus work: 1250b47e-6bc3-50da-87de-f3a354fe4a5a
DOI: 10.1101/2023.08.25.554320

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