Article

Neuron specific ablation of eIF5A or deoxyhypusine synthase leads to impairment in development and cognitive functions in mice

2021-05-13

Abstract excerpt

Eukaryotic initiation factor 5A (eIF5A) is an essential factor with a unique amino acid, hypusine, required for its activity. Hypusine is formed exclusively in eIF5A by a post-translational modification involving two enzymes, deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH). Each of the three genes, Eif5a, Dhps or Dohh is required for mouse embryonic development. Variants in EIF5A or DHPS wer...

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Literature Corpus work: d9b772ee-0cb4-5c3f-9a0e-40e268f1a5b2
DOI: 10.1101/2021.05.11.443636

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