Article

WWOX, tumour suppressor and modifier gene, as a regulator of gene expression and apoptosis in ovarian cancer

2010-01-01

Abstract excerpt

WWOX is a tumour suppressor gene, as demonstrated by increased neoplasia incidence in Wwox-knock-out animals, and is frequently disrupted in human cancers. WWOX expression reconstitution abolishes xenograft growth of lung, pancreatic, breast, ovarian and prostate cancer cells. The tumoursuppressive function of WWOX is suggested to be related to pro-apoptotic effects or interactions with potentially oncogenic trans...

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Literature Corpus work: 47a0cf03-2e5f-56e7-8e3a-00bc8b1bdbab
DOI: 10.25560/5859

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