Article

Tumor Stroma Content Regulates Penetration and Efficacy of Tumor-targeting Bacteria

2024-03-30

Abstract excerpt

Bacteria-based cancer therapy (BBCT) strains grow selectively in primary tumors and metastases, colonize solid tumors independent of genetics, and kill cells resistant to standard molecular therapy. Clinical trials of BBCT in solid tumors have not reported any survival advantage yet, partly due to the limited bacterial colonization. Collagen, abundant in primary and metastatic solid tumors, has a well-known role i...

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Literature Corpus work: 479ec902-2949-5af5-96ec-34c6a0d88068
DOI: 10.1101/2024.03.29.587035

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