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LIFUS-Driven Engineered Bacteria Reprogram Immunosuppressive Niches via Mechano-NOTCH Signaling

2025-05-26

Abstract excerpt

<title>Abstract</title> <p>The tumor microenvironment (TME) of solid tumors constructs a complex biophysical barrier with intricate interactions, including dense stromal structures and immunosuppressive networks, which severely limit the permeability and efficacy of immunotherapy. This study developed an engineered an attenuated <italic>Salmonella typhimurium</italic> VNP20009 strain encoding an acoustic reporter...

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Literature Corpus work: 3496dcd1-d1ad-5f46-9178-40792b652e75
DOI: 10.21203/rs.3.rs-6644974/v1

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