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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model.

Journal of visualized experiments : JoVE - 20 Mar 2020

Cheng Robert Y S, Patel Nimit L, Back Timothy, Basudhar Debashree, Somasundaram Veena, Kalen Joseph D, Wink David A, Ridnour Lisa A

Abstract excerpt

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited therapeutic options. When compared to patients with less aggressive breast tumors, the 5-year survival rate of TNBC patients is 77% due to their characteristic drug-resistant phenotype and metastatic burden. Toward this end, murine models have been established aimed at identifying novel therapeutic strategies limiting TNBC...

Topics

Animals
Antineoplastic Agents
Cell Line, Tumor
Drug Resistance, Neoplasm
Female
Humans
Lung Neoplasms
Mice
Phenotype
Triple Negative Breast Neoplasms
Xenograft Model Antitumor Assays

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32250353
DOI: 10.3791/60316
PMCID: PMC8459207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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