Article

Nuclear Localization of PTTG1 Promotes Migration and Invasion of Seminoma Tumor Through Activation of MMP-2.

2020-12-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Seminoma is the most common subtype of testicular germ cell tumors (TGCTs) and its molecular patterns have not been fully clarified. The pituitary tumor-transforming gene 1 (PTTG1) is a securin, inhibitor of premature sister chromatid segregation during mitosis and is overexpressed in many cancers. PTTG1 shows the ability to sustain the invasiveness of several c...

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Literature Corpus work: 4784f88b-3038-5c97-9956-61a13e878a62
DOI: 10.21203/rs.3.rs-125309/v1

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