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Pituitary tumor-transforming gene 1 and endocrine cancers: an up-to-date review through history, current insights and future perspectives

1 Jun 2025

Abstract excerpt

Pituitary tumor-transforming gene 1 (PTTG1), discovered in 1997 by Pei and Melmed, takes part in cellular replication, cell cycle control, DNA repair mechanisms, organogenesis, metabolism regulation, cellular transformation, and senescence. Its biological actions include protein-protein interactions, modulation of gene transcription, and other than intracellular and autocrine mechanisms, even paracrine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40472369
DOI: 10.1530/erc-24-0163

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