Article

Multiple competing RNA structures dynamically control alternative splicing in human ATE1 gene

2020-06-05

Abstract excerpt

The mammalian Ate1 gene encodes an arginyl transferase enzyme, which is essential for embryogenesis, male meiosis, and regulation of the cytoskeleton. Reduced levels of Ate1 are associated with malignant transformations and serve as a prognostic indicator of prostate cancer metastasis. The tumor suppressor function of Ate1 depends on the inclusion of one of the two mutually exclusive exons (MXE), exons 7a and 7...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 47815821-b267-5db7-8438-214e5ee9f709
DOI: 10.1101/2020.06.04.134791

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiple competing RNA structures dynamically control alternative splicing in human ATE1 geneDOI 10.1101/2020.06.04.134791Read

RBMX enables productive RNA processing of ultra-long exons important for genome stabilitySemantic proximity Read

Intrinsic Regulatory Role of RNA Structural Arrangement in Alternative Splicing Control.Semantic proximity Read

Intronic antisense Alu elements have a negative splicing effect on the inclusion of adjacent downstream exons.Semantic proximity Read

Angel Wing: a class of alternative splicing regulators in animalsSemantic proximity Read

A polar mechanism coordinates different regions of alternative splicing within a single gene.Semantic proximity Read

Systematic characterization of short intronic splicing-regulatory elementsSemantic proximity Read

Use of minigene systems to dissect alternative splicing elements.Semantic proximity Read

As antisense RNA gets intronic.Semantic proximity Read

A Non-sequence-specific double-stranded RNA structural element regulates splicing of two mutually exclusive exons of fibroblast growth factor receptor 2 (FGFR2).Semantic proximity Read

The deep intronic c.903+469T>C mutation in the MTRR gene creates an SF2/ASF binding exonic splicing enhancer, which leads to pseudoexon activation and causes the cblE type of homocystinuria.Semantic proximity Read

Clusters of deep intronic RbFox motifs embedded in large assembly of splicing regulators sequences regulate alternative splicingSemantic proximity Read

A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila.Semantic proximity Read