Article
A polar mechanism coordinates different regions of alternative splicing within a single gene.
Molecular cell - 5 Aug 2005
Fededa Juan P, Petrillo Ezequiel, Gelfand Mikhail S, Neverov Alexei D, Kadener Sebastián, Nogués Guadalupe, Pelisch Federico, Baralle Francisco E, Muro Andrés F, Kornblihtt Alberto R
Abstract excerpt
Alternative splicing plays a key role in generating protein diversity. Transfections with minigenes revealed coordination between two distant, alternatively spliced exons in the same gene. Mutations that either inhibit or stimulate inclusion of the upstream alternative exon deeply affect inclusion of the downstream one. However, similar mutations at the downstream alternative exon have little effect on the...
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