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Article

Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.

The Journal of clinical endocrinology and metabolism - 1 Sept 2013

Landa Iñigo, Ganly Ian, Chan Timothy A, Mitsutake Norisato, Matsuse Michiko, Ibrahimpasic Tihana, Ghossein Ronald A, Fagin James A

Abstract excerpt

BACKGROUND: TERT encodes the reverse transcriptase component of telomerase, which adds telomere repeats to chromosome ends, thus enabling cell replication. Telomerase activity is required for cell immortalization. Somatic TERT promoter mutations modifying key transcriptional response elements were recently reported in several cancers, such as melanomas and gliomas. OBJECTIVES: The objectives of the study were: 1)...

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Share to Carcinoma, Papillary
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

Open in PubMed Open full text

Identifiers

PMID: 23833040
DOI: 10.1210/jc.2013-2383
PMCID: PMC3763971

Genes

TERT
BRAF
RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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