Article

LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity

2020-03-05

Abstract excerpt

<h4>ABSTRACT</h4> WNT signalling is a developmental pathway which plays an important role in post-natal bone accrual. We have previously shown, that in addition to exhibiting extreme high bone mass, subjects with rare gain-of-function (GoF) mutations in the WNT co-receptor LRP5 also display increased lower-body fat mass. Here, we demonstrate using human physiological studies in GoF LRP5 mutation carriers and gluc...

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Literature Corpus work: 4759aeff-7797-5aba-b86f-6f51b10d04f8
DOI: 10.1101/2020.03.04.976647

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