Article
Localisation of Nramp1 in macrophages: modulation with activation and infection.
Journal of cell science - 1 Oct 1998
Searle S, Bright N A, Roach T I, Atkinson P G, Barton C H, Meloen R H, Blackwell J M
Abstract excerpt
The murine natural resistance-associated macrophage protein, Nramp1, has multiple pleiotropic effects on macrophage activation and regulates survival of intracellular pathogens including Leishmania, Salmonella and Mycobacterium species. Nramp1 acts as an iron transporter, but precisely how this r...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Carrier Proteins
- Cation Transport Proteins
- Cell Line
- Endosomes
- Epitope Mapping
- Leishmania major
- Lysosomes
- Macrophage Activation
- Macrophages
- Membrane Proteins
- Mice
- Microscopy, Confocal
- Microscopy, Immunoelectron
- Molecular Sequence Data
- Mutation