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Dual Transcriptome Profiling of<i>Leishmania</i>-Infected Human Macrophages Reveals Distinct Reprogramming Signatures

11 May 2016

Abstract excerpt

UNLABELLED: Macrophages are mononuclear phagocytes that constitute a first line of defense against pathogens. While lethal to many microbes, they are the primary host cells of Leishmania spp. parasites, the obligate intracellular pathogens that cause leishmaniasis. We conducted transcriptomic profiling of two Leishmania species and the human macrophage over the course of intracellular infection by using...

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PMID: 27165796
DOI: 10.1128/mbio.00027-16

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