Article

<i>Anaplasma phagocytophilum</i> Subversion of Host Hepcidin-Ferroportin Iron Nutritional Immunity

2026-03-04

Abstract excerpt

<h4>ABSTRACT</h4> Obligatory intracellular bacterium Anaplasma phagocytophilum ( Aph ) causes an emerging infectious disease called human granulocytic anaplasmosis. Within host cells, Aph proliferates in a membrane-bound vacuole ( Aph -vacuole), to which all required nutrients must be routed, including essential iron. Here, using a fluorescent labile iron-binding dye, we found that Aph -vacuoles are enriched...

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Literature Corpus work: c043af4d-2408-5fa1-8e2a-c32bc99e88c4
DOI: 10.64898/2026.03.02.709072

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