Article

Label-free Identification of Protein Aggregates Using Deep Learning

2023-04-23

Abstract excerpt

Protein misfolding and aggregation play central roles in the pathogenesis of various neurodegenerative diseases (NDDs), including Huntington’s disease, which is caused by a genetic mutation that leads to a polyglutamine repeat length > 35 in exon 1 of the Huntingtin protein (Httex1). Current research on protein aggregation often involves the use of fluorescent labels to visualize and monitor the dynamics of protei...

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Literature Corpus work: 628f098e-b978-5d44-b367-5373baf06cb2
DOI: 10.1101/2023.04.21.537833

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