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Article

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations.

The Journal of clinical investigation - 1 Sept 2013

Semenza Gregg L

Abstract excerpt

Hypoxia occurs frequently in human cancers and induces adaptive changes in cell metabolism that include a switch from oxidative phosphorylation to glycolysis, increased glycogen synthesis, and a switch from glucose to glutamine as the major substrate for fatty acid synthesis. This broad metabolic reprogramming is coordinated at the transcriptional level by HIF-1, which functions as a master regulator to balance...

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Share to Adaptation, Physiological
Share to Cell Hypoxia
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Energy Metabolism

Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Share to Neoplasms

Share to Oncogenes

Source

Open in PubMed Open full text

Identifiers

PMID: 23999440
DOI: 10.1172/JCI67230
PMCID: PMC3754249

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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