Article

Engineering immunotoxin-equipped effector cells and evaluation in primary human immune cells

2025-12-11

Abstract excerpt

Lethal toxins could become potent therapies against cancer, but their clinical utility is limited by adverse events upon systemic administration. These could be reduced if the toxins were delivered by effector cells that specifically infiltrate cancers, thereby releasing toxins locally into the tumor microenvironment. One of the challenges underlying this strategy is that cells delivering toxins would have to be r...

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Literature Corpus work: 47202adc-e1b1-5920-bcf6-128368febfe1
DOI: 10.64898/2025.12.09.691975

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