A Genetically Encoded Endogenous Antibody Recruitment Strategy for Innate Immune‐Mediated Killing of Cancer Cells

Abstract excerpt

Antibody-recruiting molecules (ARMs) are bivalent molecules that contain a cell-binding domain and an antibody-binding domain. ARMs are designed to redirect circulating endogenous antibodies from the bloodstream to the surface of cancer cells and thereby trigger innate immune-mediated killing of the latter. The current generation of clinically explored ARMs relies on synthetic small molecule haptens. However,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Immune Cell Function and Interaction
• Share to Immunotherapy and Immune Responses
• Share to Monoclonal and Polyclonal Antibodies Research