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Article

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A.

Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2012

Mazor Ronit, Vassall Aaron N, Eberle Jaime A, Beers Richard, Weldon John E, Venzon David J, Tsang Kwong Y, Benhar Itai, Pastan Ira

Abstract excerpt

Recombinant immunotoxins (RITs) are chimeric proteins that are being developed for cancer treatment. We have produced RITs that contain PE38, a portion of the bacterial protein Pseudomonas exotoxin A. Because the toxin is bacterial, it often induces neutralizing antibodies, which limit the number of treatment cycles and the effectiveness of the therapy. Because T cells are essential for antibody responses to...

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Identifiers

PMID: 23213206
DOI: 10.1073/pnas.1218138109
PMCID: PMC3529021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A.PMID 23213206Read ↗

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