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Article

Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy

16 Apr 2012

Abstract excerpt

HA22 is a recombinant immunotoxin composed of an anti-CD22 Fv fused to a portion of Pseudomonas exotoxin A. HA22 produced a high rate of complete remissions in drug-resistant hairy cell leukemia and has a lower response rate in pediatric acute lymphoblastic leukemia (ALL). To understand why patients with ALL have poorer responses, we isolated an ALL cell line that is resistant to killing by HA22. The resistance...

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PMID: 22509046
DOI: 10.1073/pnas.1204523109

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