Article

Genomic profiling of cell lines reveals hidden research bias and caveats

2020-02-24

Abstract excerpt

Cancer cell lines are extremely valuable tools for carcinoma research. Biodiversity of cell lines and continuous random mutation in cell lines during passage, however, might result in phenotypic inconsistency and lead to biased experimental conclusions. Using statistics based on known and inferred protein interaction networks, as well as public research literature database, our study shows that essential driver ge...

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Literature Corpus work: 2ece31d4-13a6-536f-8b84-b6684d577d70
DOI: 10.1101/2020.02.23.961516

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