Article
Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.
Experimental hematology - 1 Jul 2016
Griffith Malachi, Griffith Obi L, Krysiak Kilannin, Skidmore Zachary L, Christopher Matthew J, Klco Jeffery M, Ramu Avinash, Lamprecht Tamara L, Wagner Alex H, Campbell Katie M, Lesurf Robert, Hundal Jasreet, Zhang Jin, Spies Nicholas C, Ainscough Benjamin J, Larson David E, Heath Sharon E, Fronick Catrina, O'Laughlin Shelly, Fulton Robert S, Magrini Vincent, McGrath Sean, Smith Scott M, Miller Christopher A, Maher Christopher A, Payton Jacqueline E, Walker Jason R, Eldred James M, Walter Matthew J, Link Daniel C, Graubert Timothy A, Westervelt Peter, Kulkarni Shashikant, DiPersio John F, Mardis Elaine R, Wilson Richard K, Ley Timothy J
Abstract excerpt
The genomic events responsible for the pathogenesis of relapsed adult B-lymphoblastic leukemia (B-ALL) are not yet clear. We performed integrative analysis of whole-genome, whole-exome, custom capture, whole-transcriptome (RNA-seq), and locus-specific genomic assays across nine time points from a patient with primary de novo B-ALL. Comprehensive genome and transcriptome characterization revealed a dramatic tumor...
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