Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel pancreatic tumour and stellate cell 3D co-culture spheroid model.

BMC cancer - 27 May 2020

Norberg K J, Liu X, Fernández Moro C, Strell C, Nania S, Blümel M, Balboni A, Bozóky B, Heuchel R L, Löhr J M

Abstract excerpt

BACKGROUND: Pancreatic ductal adenocarcinoma is a devastating disease with poor outcome, generally characterized by an excessive stroma component. The purpose of this study was to develop a simple and reproducible in vitro 3D-assay employing the main constituents of pancreatic ductal adenocarcinoma, namely pancreatic stellate and cancer cells. METHOD: A spheroid assay, directly co-culturing human pancreatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Pancreatic Ductal
Share to Cell Communication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Coculture Techniques

Share to Microscopy, Electron

Share to Pancreatic Neoplasms

Share to Real-Time Polymerase Chain Reaction

Share to Spheroids, Cellular

Source

Open in PubMed Open full text

Identifiers

PMID: 32460715
DOI: 10.1186/s12885-020-06867-5
PMCID: PMC7251727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel pancreatic tumour and stellate cell 3D co-culture spheroid model.PMID 32460715Read ↗

3D heterospecies spheroids of pancreatic stroma and cancer cells demonstrate key phenotypes of pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor.Semantic proximity Read ↗

Pancreatic Cancer Patient-Derived Organoid Platforms: A Clinical Tool to Study Cell- and Non-Cell-Autonomous Mechanisms of Treatment ResponseSemantic proximity Read ↗

Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture systemSemantic proximity Read ↗

The Diverse Applications of Pancreatic Ductal Adenocarcinoma OrganoidsSemantic proximity Read ↗

Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer CellsSemantic proximity Read ↗

Microfluidic co-culture of pancreatic tumor spheroids with stellate cells as a novel 3D model for investigation of stroma-mediated cell motility and drug resistanceSemantic proximity Read ↗

Exploring human pancreatic organoid modelling through single-cell RNA sequencing analysisSemantic proximity Read ↗

Inter‐ and intra‐tumoural heterogeneity in cancer‐associated fibroblasts of human pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Transcriptome Profiling of Panc-1 Spheroid Cells with Pancreatic Cancer Stem Cells Properties Cultured by a Novel 3D Semi-Solid SystemSemantic proximity Read ↗

Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo modelsSemantic proximity Read ↗

The Cellular Origins of Cancer-Associated Fibroblasts and Their Opposing Contributions to Pancreatic Cancer GrowthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.