Article

Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function

2022-09-20

Abstract excerpt

Crosstalk between cancer and stellate cells is pivotal in pancreatic cancer, resulting in differentiation of stellate cells into myofibroblasts that drive. To assess co-operative mechanisms in a 3D context, we generated chimeric spheroids using human and mouse cancer and stellate cells. Species-specific deconvolution of bulk-RNA sequencing data revealed cell type-specific transcriptomes underpinning invasion. This...

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Literature Corpus work: 5b3ec85c-c7b0-5bd5-b25d-2cbad17653b6
DOI: 10.1101/2022.09.20.508645

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