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PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome

1 Mar 2023

Abstract excerpt

BACKGROUND: Polycystic ovary syndrome (PCOS) is one of the most common diseases with the coexistence of reproductive malfunction and metabolic disorders. Previous studies have found increased branched chain amino acid (BCAA) levels in women with PCOS. However, it remains unclear whether BCAA metabolism is causally associated with the risk of PCOS. METHODS: -dependent 1K (PPM1K) was further explored by using...

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PMID: 36863088
DOI: 10.1016/j.ebiom.2023.104492

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