Article

Macrophages redeploy functional cancer cell surface proteins following phagocytosis

2024-09-25

Abstract excerpt

Macrophage-mediated phagocytosis is a vital innate immune process altered in cancer. We show here that tumor-associated macrophages (TAMs) redeploy intact cell surface proteins from cancer cells to their own cell surface. We initially observed the canonical epithelial cancer surface marker EpCAM on the surface of TAMs in primary human solid tumors but not paired peripheral blood macrophages. In a murine model of m...

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Literature Corpus work: 46e9020d-503b-5b9e-82c8-54eace6a6e5e
DOI: 10.1101/2024.09.23.613776

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