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Article

PI3 kinase signaling is involved in Aβ-induced memory loss in <i>Drosophila</i>

29 Mar 2010

Abstract excerpt

Multiple intracellular signals are altered in Alzheimer's disease brain tissues, including the PI3K/Akt pathway. However, the pathological relevance of such alterations is poorly understood. In vitro studies yield results that seem to be consistent with the conventional perception in which an up-regulation of the cell survival pathway, PI3K pathway, is protective in Alzheimer's disease pathogenesis. The current...

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PMID: 20351282
DOI: 10.1073/pnas.0909314107

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