Article

A CRISPR-based genetic screen in <i>Bacteroides thetaiotaomicron</i> reveals a small RNA modulator of bile susceptibility

2023-07-03

Abstract excerpt

Microbiota-centric interventions are limited by our incomplete understanding of the gene functions of many of its constituent species. This applies in particular to small RNAs (sRNAs), which are emerging as important regulators in microbiota species, yet tend to be missed by traditional functional genomics approaches. Here, we establish CRISPR interference (CRISPRi) in the abundant microbiota member Bacteroides t...

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Literature Corpus work: 46def3f5-a5ce-5cc2-b021-9004a9b6dabc
DOI: 10.1101/2023.07.03.547467

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