Article

Anionic lipid catalyzes the generation of cytotoxic insulin oligomers

2025-01-18

Abstract excerpt

Misfolding and aggregation of proteins into amyloidogenic assemblies are key features of several metabolic and neurodegenerative diseases. Human insulin has long been known to form amyloid fibrils under various conditions, which affects its bioavailability and function. Clinically, insulin aggregation at recurrent injection sites poses a challenge for diabetic patients who rely on insulin therapy. Furthermore, dec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 46dc9c11-8502-5f5e-a081-a67356404307
DOI: 10.1101/2025.01.14.633028

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Anionic lipid catalyzes the generation of cytotoxic insulin oligomersDOI 10.1101/2025.01.14.633028Read

Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus.Semantic proximity Read

Rationally designed, nontoxic, nonamyloidogenic analogues of human islet amyloid polypeptide with improved solubility.Semantic proximity Read

Developing peptide-based inhibitors of amylin aggregation as a novel treatment for type 2 diabetesSemantic proximity Read

Cytotoxicity of 1-deoxysphingolipid Unraveled by Genome-wide Genetic Screens and LipidomicsSemantic proximity Read

Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity.Semantic proximity Read

1-Palmitoyl-2-(9'-oxononanoyl)-sn-glycero-3-phosphocholine, an oxidized phospholipid, accelerates Finnish type familial gelsolin amyloidosis in vitro.Semantic proximity Read

Mitochondrial membranes modify mutant huntingtin aggregation.Semantic proximity Read

A potential anti-amyloidogenic therapy for type 2 diabetes based on the QBP1 peptideSemantic proximity Read

Synergistic Effect of Mutations in the Amyloidogenic Core of Human Amylin (hAM) Affords a New Potent Inhibitor of hAM Fibrillation: Computational Design and Experimental Validation.Semantic proximity Read

Structural dissection of the first events following membrane binding of the islet amyloid polypeptideSemantic proximity Read

Lipid-induced conformational transition of amyloid beta peptide fragments.Semantic proximity Read

Potato protein- based carriers for enhancing bioavailability of astaxanthinSemantic proximity Read