Article

Cytotoxicity of 1-deoxysphingolipid Unraveled by Genome-wide Genetic Screens and Lipidomics

2019-06-03

Abstract excerpt

Hereditary Sensory and Autonomic Neuropathy (HSAN) type IA and IC are caused by elevated levels of an atypical class of lipid named 1-deoxysphingolipid (DoxSL). How elevated levels of DoxSL perturb the physiology of the cell and how the perturbations lead to HSAN IA/C are largely unknown. In this study, we show that C 26 -1-deoxydihydroceramide (C 26 -DoxDHCer) is highly toxic to the cell, while C 16 - and C 1...

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Literature Corpus work: 3e3c536b-5653-5360-a978-83614a9ee381
DOI: 10.1101/658690

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