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Article

Understanding the Pathogenicity of Parkin Catalytic Domain Mutants

2024-07-29

Abstract excerpt

Mutations in the E3 ubiquitin ligase parkin cause a familial form of Parkinson’s disease (PD). Parkin and the mitochondrial kinase PINK1 assure quality control of mitochondria through selective autophagy of mitochondria (mitophagy). Whereas numerous parkin mutations have been functionally characterized and their structural basis revealed, several pathogenic PD mutations found in the catalytic RING2 domain remain p...

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Literature Corpus work
eb2864a9-4648-50e2-b865-cccbc7ad5666
DOI
10.1101/2024.07.29.605699
Open publication

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Understanding the Pathogenicity of Parkin Catalytic Domain MutantsDOI 10.1101/2024.07.29.605699
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