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The Landscape of <i>Parkin</i> Variants Reveals Pathogenic Mechanisms and Therapeutic Targets in Parkinson’s Disease

2018-10-17

Abstract excerpt

Mutations in Parkin ( PARK2 ), which encodes an E3 ubiquitin ligase implicated in mitophagy, are the most common cause of early onset Parkinson’s Disease (PD). Hundreds of naturally occurring Parkin variants have been reported, both in PD patient and population databases. However, the effects of the majority of these variants on the function of Parkin and in PD pathogenesis remains unknown. Here we develop a fr...

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Literature Corpus work
a66014fb-2df2-5843-a12d-97b91d919046
DOI
10.1101/445551
Open publication

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The Landscape of <i>Parkin</i> Variants Reveals Pathogenic Mechanisms and Therapeutic Targets in Parkinson’s DiseaseDOI 10.1101/445551
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