Article

Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts

2020-01-14

Abstract excerpt

The decoy exon model has been proposed to regulate a subset of intron retention (IR) events involving predominantly larger introns (>1kb). Splicing reporter studies have shown that decoy splice sites are essential for activity, suggesting that decoys act by engaging intron-terminal splice sites and competing with cross-intron interactions required for intron excision. The decoy model predicts that antisense oligon...

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Literature Corpus work: ef483e84-8afa-58f2-b712-748fdeeff1a2
DOI: 10.1101/2020.01.13.902544

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