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Changes at V2 apex of HIV-1 Clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

2021-06-15

Abstract excerpt

<h4>Summary</h4> HIV-1 clade C envelope immunogens that elicit both neutralizing and non-neutralizing V1V2-scaffold specific antibodies (protective correlates from RV144 human trial) are urgently needed due to the prevalence of this clade in the most impacted regions worldwide. To achieve this, we introduced structure-guided changes followed by consensus-C sequence-guided optimizations at the V2-region to generat...

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Literature Corpus work
469ba609-eeaf-5b3d-a7df-a869a779a5c3
DOI
10.1101/2021.06.15.447100
Open publication

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Changes at V2 apex of HIV-1 Clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodiesDOI 10.1101/2021.06.15.447100
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