Article
Stabilized HIV-1 envelope glycoprotein trimers lacking the V1V2 domain, obtained by virus evolution.
The Journal of biological chemistry - 19 Nov 2010
Bontjer Ilja, Melchers Mark, Eggink Dirk, David Kathryn, Moore John P, Berkhout Ben, Sanders Rogier W
Abstract excerpt
The envelope glycoproteins (Env) are the focus of HIV-1 vaccine development strategies based on the induction of humoral immunity, but the mechanisms the virus has evolved to limit the induction and binding of neutralizing antibodies (NAbs) constitute substantial obstacles. Conserved neutralization epitopes are shielded by variable regions and carbohydrates, so one strategy to increase their exposure and, it is...
Topics
- Amino Acid Sequence
- Blotting, Western
- Directed Molecular Evolution
- HIV Antibodies
- HIV Antigens
- HIV Infections
- HIV-1
- Humans
- Immunoprecipitation
- Models, Molecular
- Molecular Sequence Data