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Article

The V1V2 Region of HIV-1 gp120 Forms a Five-Stranded Beta Barrel

28 May 2015

Abstract excerpt

UNLABELLED: The region consisting of the first and second variable regions (V1V2) of gp120 plays vital roles in the functioning of the HIV-1 envelope (Env). V1V2, which harbors multiple glycans and is highly sequence diverse, is located at the Env apex and stabilizes the trimeric gp120 spike on the virion surface. It shields V3 and the coreceptor binding sites in the prefusion state and exposes them upon CD4...

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PMID: 26018158
DOI: 10.1128/jvi.00754-15

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