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KDM3B shows tumor-suppressive activity and transcriptionally regulatesHOXA1through retinoic acid response elements in acute myeloid leukemia

25 May 2017

Abstract excerpt

KDM3B reportedly shows both tumor-suppressive and tumor-promoting activities in leukemia. The function of KDM3B is likely cell-type dependent and its seeming functional discordance may reflect its phenotypic dependence on downstream targets. Here, we first showed the underexpression of KDM3B in acute myeloid leukemia (AML) patients and AML cell lines with MLL-AF6/9 or PML-RARA translocations. Overexpression of...

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PMID: 28540746
DOI: 10.1080/10428194.2017.1324156

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