Article

Pharmacogenetics in critical care: the expression of rs776746 polymorphism and acetaminophen response in sepsis and septic shock

2022-08-24

Abstract excerpt

<h4>Background: </h4> Pharmacogenetics could represent a further resource to understand the interindividual heterogeneity of response of the host to the insult and to medications and to provide a personalized approach to the critical care patient. <h4>Methods:</h4> Secondary analysis of data from the prospective observational study NCT02750163. The expression of two polymorphisms of hepatic metabolism of acetamino...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4681e6c7-3e32-5484-aa44-d4b52bc14ec4
DOI: 10.21203/rs.3.rs-1971505/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenetics in critical care: the expression of rs776746 polymorphism and acetaminophen response in sepsis and septic shockDOI 10.21203/rs.3.rs-1971505/v1Read

Pharmacogenetics in critical care: association between CYP3A5 rs776746 A/G genotype and acetaminophen response in sepsis and septic shock.Semantic proximity Read

Pharmacogenomic influence on sepsis outcome in critically ill patients.Semantic proximity Read

The impact of acetaminophen on reducing the incidence of postoperative delirium in elderly patients with sepsis in the ICU: A retrospective study and Mendelian randomization analysisSemantic proximity Read

Patient Stratification in Sepsis: Using Metabolomics to Detect Clinical Phenotypes, Sub-Phenotypes and Therapeutic ResponseSemantic proximity Read

Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure.Semantic proximity Read

Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure.Semantic proximity Read

Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure.Semantic proximity Read

Population-specific Risk of Pharmacogenomics-related Inaccurate Drug Dosing of ICU PatientsSemantic proximity Read

Hemodynamic phenotype-based, capillary refill time-targeted resuscitation in early septic shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial study protocol.Semantic proximity Read

Septic Shock: Phenotypes and Outcomes.Semantic proximity Read

Effects of the 34C>T Variant of the AMPD1 Gene on Immune Function, Multi-Organ Dysfunction, and Mortality in Sepsis Patients.Semantic proximity Read

Hypoxia inducible factor-1 alpha and prolinhydroxlase 2 polymorphisms in patients with severe sepsis: a prospective observational trial.Semantic proximity Read