Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure.

Journal of hepatology - 1 Jul 1998

Bernal W, Donaldson P, Underhill J, Wendon J, Williams R

Abstract excerpt

BACKGROUND/AIMS: High levels of tumor necrosis factor-alpha are associated with an increased risk of severe encephalopathy in acute liver failure, and experimental studies suggest that tumor necrosis factor-alpha plays a role in the development of acetaminophen (paracetamol)-induced liver injury and associated multiple organ failure. Inter-individual variations in the production of tumor necrosis factor-alpha...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Alleles
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA-DR Antigens

Share to Logistic Models

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 9696492
DOI: 10.1016/s0168-8278(98)80178-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure.PMID 9696492Read ↗

Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure.Semantic proximity Read ↗

Pharmacogenetics in critical care: the expression of rs776746 polymorphism and acetaminophen response in sepsis and septic shockSemantic proximity Read ↗

Genetic Association of Single Nucleotide Polymorphisms with Acetaminophen-Induced Hepatotoxicity.Semantic proximity Read ↗

A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis.Semantic proximity Read ↗

The Genomics of Elevated ALT and Adducts in Therapeutic Acetaminophen Treatment: a Pilot Study.Semantic proximity Read ↗

Lower blood lactate and higher circulating natural killer cells at admission predict spontaneous survival in non-acetaminophen induced acute Liver failureSemantic proximity Read ↗

Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity.Semantic proximity Read ↗

Pharmacogenetics in critical care: association between CYP3A5 rs776746 A/G genotype and acetaminophen response in sepsis and septic shock.Semantic proximity Read ↗

Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure.Semantic proximity Read ↗

Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses.Semantic proximity Read ↗

Polymorphisms of the TNF, CD14, and HSPA1B genes in patients with acute alcohol-induced pancreatitis.Semantic proximity Read ↗

Tumor necrosis factor-β Nco1 polymorphism and susceptibility to sepsis following major elective surgery.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.