Article
Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure.
Journal of hepatology - 1 Jul 1998
Bernal W, Donaldson P, Underhill J, Wendon J, Williams R
Abstract excerpt
BACKGROUND/AIMS: High levels of tumor necrosis factor-alpha are associated with an increased risk of severe encephalopathy in acute liver failure, and experimental studies suggest that tumor necrosis factor-alpha plays a role in the development of acetaminophen (paracetamol)-induced liver injury...
Topics
- APACHE
- Acetaminophen
- Adolescent
- Adult
- Alleles
- Analgesics, Non-Narcotic
- Chemical and Drug Induced Liver Injury
- Female
- Genotype
- HLA-DR Antigens
- Hepatic Encephalopathy
- Humans
- Liver Failure, Acute
- Logistic Models
- Male
- Middle Aged
- Multiple Organ Failure
- Polymerase Chain Reaction