Article
Pharmacogenomic influence on sepsis outcome in critically ill patients.
Le infezioni in medicina - 1 Mar 2017
Allegra Sarah, Fatiguso Giovanna, Baietto Lorena, Corcione Silvia, Favata Fabio, Ariaudo Alessandra, Pagani Nicole, Ranieri Vito Marco, De Rosa Francesco Giuseppe, Di Perri Giovanni, D'Avolio Antonio
Abstract excerpt
In infectious and inflammatory diseases, pharmacogenetics affects treatment efficacy and toxicity. Moreover, recent studies suggest its important role in predicting the clinical outcome of sepsis. Our aim was to investigate the influence of single nucleotide polymorphisms (SNPs) in genes which we supposed to be involved in linezolid elimination upon sepsis outcome. Fourteen ICU-admitted patients in therapy with...
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