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Article

Coronavirus infection, ER stress, apoptosis and innate immunity

17 Jun 2014

Abstract excerpt

The replication of coronavirus, a family of important animal and human pathogens, is closely associated with the cellular membrane compartments, especially the endoplasmic reticulum (ER). Coronavirus infection of cultured cells was previously shown to cause ER stress and induce the unfolded protein response (UPR), a process that aims to restore the ER homeostasis by global translation shutdown and increasing the...

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PMID: 24987391
DOI: 10.3389/fmicb.2014.00296

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