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Article

Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus

18 Nov 2019

Abstract excerpt

The unfolded protein response (UPR) in the endoplasmic reticulum (ER) constitutes a critical component of host innate immunity against microbial infections.In this report, we show that porcine reproductive and respiratory syndrome virus (PRRSV) utilizes the UPR machinery for its own benefit.We provide evidence that the virus targets the UPR central regulator GRP78 for proteasomal degradation via a mechanism that...

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PMID: 31738790
DOI: 10.1371/journal.ppat.1008169

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